Search on: BONE 4-CARBOXYGLUTAMIC PROTEIN 
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Descriptor English:   Osteocalcin 
Descriptor Spanish:   Osteocalcina 
Descriptor Portuguese:   Osteocalcina 
Synonyms English:   4-Carboxyglutamic Protein, Bone
Bone gamma-Carboxyglutamic Acid Protein
4 Carboxyglutamic Protein, Bone
Bone 4-Carboxyglutamic Protein
Bone gamma Carboxyglutamic Acid Protein
Calcium Binding Protein, Vitamin K Dependent
Protein, Bone 4-Carboxyglutamic
Protein, Bone Gla
Vitamin K Dependent Bone Protein
Bone Gla Protein
Calcium-Binding Protein, Vitamin K-Dependent
Vitamin K-Dependent Bone Protein
Gla Protein, Bone  
Tree Number:   D12.776.157.125.700
Definition English:   Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX. 
History Note English:   90; GLA-PROTEIN was see OSTEOCACLIN 1990-96 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   24820 
Unique Identifier:   D015675 

Occurrence in VHL: 		 

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